Application of the Knorr reaction for the directional synthesis of pyrazole derivative as a biologically active co-ligandes of gold glyco-nanoparticles

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Based on the reaction of acetylacetone with 6-mercaptohexanoic and 11-mercaptoundecanoic acid hydrazides, a method was developed for the synthesis of previously unknown 1-(ω-mercaptoacyl)-3,5-dimethylpyrazole as promising сo-ligand for the preparation of gold glyco-nanoparticles for biomedical purposes.

作者简介

A. Ershov

Institute of Macromolecular Compounds of Russian Academy of Sciences

Email: ershov305@mail.ru

A. Martynenkov

Institute of Macromolecular Compounds of Russian Academy of Sciences

I. Lagoda

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation

A. Batyrenko

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation

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