Aspirantskiy Vestnik PovolzhiyaAspirantskiy Vestnik PovolzhiyaАспирантский вестник Поволжья2072-23542410-3764Samara State Medical University67772810.35693/AVP677728PHARMACEUTICAL CHEMISTRY, PHARMACOGNOSYФАРМАЦЕВТИЧЕСКАЯ ХИМИЯ, ФАРМАКОГНОЗИЯResearch ArticleEutectic mixtures in the design of drugsЭвтектические композиции в дизайне лекарственных средствhttps://orcid.org/0009-0009-3058-0046SeryakovaAnna N.СеряковаАнна Николаевна
Russian Federation

senior lecturer of the Department of Chemistry of the Institute of Pharmacy

старший преподаватель кафедры химии Института фармации

a.n.seryakova@samsmu.ruVoroninAleksandrВоронинАлександр Васильевич
Russian Federation

Dr. Sci. (Pharmacy), Professor, Director of the Institute of Pharmacy

доктор фарм. наук, профессор, директор Института фармации

a.v.voronin@samsmu.ruSamara State Medical UniversityФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России070520252406202525275822503202504042025Copyright ©; 2025, Seryakova A., Voronin A.Copyright ©; 2025, Серякова А.Н., Воронин А.В.2025Seryakova A., Voronin A.Серякова А.Н., Воронин А.В.https://creativecommons.org/licenses/by/4.0https://aspvestnik.ru/2410-3764/article/view/677728

Drug development is a stage of modern drug design aimed at improving the biopharmaceutical characteristics of drugs, such as solubility, chemical stability, bioavailability, and pharmacological activity. The synthesis of solid dispersed systems of the eutectic type is one of the alternative options for the creation of new medicines based on known active pharmaceutical substances with improved and predictable properties. Eutectic mixtures consist of two or more components, and are characterized by certain compositions and a low melting point. The features of the microstructure of eutectic affect its physico-chemical properties, which determines the potential use of these systems in the pharmaceutical industry. The article provides an overview of scientific research aimed at studying eutectic compositions and analyzing their characteristics: solubility and dissolution rate, therapeutic efficacy and technological properties.

Разработка лекарственных средств – этап современного дизайна лекарств, целью которого является совершенствование биофармацевтических характеристик препаратов, таких как растворимость, химическая стабильность, биодоступность, фармакологическая активность. Синтез твердых дисперсных систем эвтектического типа – один из альтернативных вариантов создания новых лекарственных средств на основе известных активных фармацевтических субстанций с улучшенными и прогнозируемыми свойствами. Эвтектические смеси состоят из двух и более компонентов и характеризуются определенным составов и пониженной температурой плавления. Особенности микроструктуры эвтектик влияют на ее физико-химические свойства, что обуславливает потенциал использования данных систем в фармацевтической промышленности.

В статье представлен обзор научных исследований, направленных на изучение эвтектических композиций и анализ их характеристик: растворимости и скорости растворения, терапевтической эффективности и технологических свойств.

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