Biologically active symmetric and asymmetric dicationic bis-isatinhydrazones: which is better - complicing or simplifying the structure of the spacer?

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Abstract

The interaction of bis-isatins containing a 1,-ω-alkylene, arylene, or alkyluracil spacer with ammonium acetohydrazides yielded a series of dicationic isatin-3-acylhydrazones with symmetric and asymmetric structures. It was shown that the antimicrobial activity of the new compounds depends on the structure of the spacer and the nature of the substituent in the aromatic fragment. Derivatives based on 5-substituted isatins, in which heterocyclic fragments are linked by an alkylene chain of 9 and 10 carbon atoms, exhibit a bactericidal effect against resistant strains of Staphylococcus aureus at the level of norfloxacin and the pathogen fungus P. cactorum , which causes plant late blight.

About the authors

A. V. Bogdanov

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

Email: abogdanov@inbox.ru

A. D. Voloshina

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

S. K. Amerkhanova

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

A. P. Lyubina

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

O. M. Tsivileva

Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences (IBPPM RAS)

R. R. Rakhmatullin

Kazan national research technological university

V. F. Mironov

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

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