N-arylation of 1,2,4- and 1,3,4-oxadiazolones under the conditions of activitated aromatic nucleophilic substitution

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Abstract

The possibilities of N -arylation of 1,2,4-oxadiazol-5(4 Н )-ones and 1,3,4-oxadiazol-2(3 Н )-ones with various electron-deficient chloro- and fluorine-substituted nitroarenes under the conditions of classical activated nucleophilic substitution were studied. A significant difference was shown in the reactivity of 1,2,4- and 1,3,4-oxadiazolones in N -arylation reactions. Methods for the synthesis of N-nitroaryl derivatives have been developed.1,2,4- and 1,3,4-oxadiazolones, providing yields of target products with sufficient purity and good yields at the level of 65-96%.

About the authors

A. S Konstantinova

Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University;Russian State University named after A.N. Kosygin (Technology. Design. Art)

Email: a.konstantinova@yspu.org

A. A Shetnev

Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University

Email: a.shetnev@list.ru

A. S Volobueva

Saint Petersburg Pasteur Institute

M. K Korsakov

Russian State University named after A.N. Kosygin (Technology. Design. Art)

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