Synthesis and antiviral activity of new dimers of 1,2,3-triazolyl pyrimidine nucleoside analogues

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Abstract

A series of new dimers of pyrimidine nucleoside analogues have been synthesized. The dimers are composed of two uracil or thymine fragments linked at N3 through a polymethylene bridge and bearing a β-D-ribofuranose residue linked to N1 of the nucleobase through a 1,2,3-triazolylalkyl spacer. Biological screening revealed that some of the synthesized dimers are active against influenza A (H1N1) virus and coxsackievirus B3 with IC50 values of 13 and 4.5 μM, respectively.

About the authors

O. V. Andreeva

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Science

Author for correspondence.
Email: andreeva@iopc.ru
ORCID iD: 0000-0001-5518-8395
Russian Federation, Arbuzov str., 8, Kazan, 420088

L. F. Saifina

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Science

Email: andreeva@iopc.ru
ORCID iD: 0000-0001-7504-1331
Russian Federation, Arbuzov str., 8, Kazan, 420088

M. M. Shulaeva

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Science

Email: andreeva@iopc.ru
ORCID iD: 0000-0001-6014-0177
Russian Federation, Arbuzov str., 8, Kazan, 420088

M. G. Belenok

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Science

Email: andreeva@iopc.ru
ORCID iD: 0000-0002-0906-8226
Russian Federation, Arbuzov str., 8, Kazan, 420088

V. V. Zarubaev

Pasteur Institute of Epidemiology and Microbiology

Email: andreeva@iopc.ru
ORCID iD: 0000-0002-5224-3771
Russian Federation, Mira Str.,14, Saint Petersburg, 197101

A. V. Slita

Pasteur Institute of Epidemiology and Microbiology

Email: andreeva@iopc.ru
ORCID iD: 0000-0001-8229-0715
Russian Federation, Mira Str.,14, Saint Petersburg, 197101

A. S. Volobueva

Pasteur Institute of Epidemiology and Microbiology

Email: andreeva@iopc.ru
ORCID iD: 0000-0003-0839-852X
Russian Federation, Mira Str.,14, Saint Petersburg, 197101

V. E. Semenov

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Science

Email: andreeva@iopc.ru
ORCID iD: 0000-0001-8350-2433
Russian Federation, Arbuzov str., 8, Kazan, 420088

V. E. Kataev

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Science

Email: andreeva@iopc.ru
ORCID iD: 0000-0002-2767-2793
Russian Federation, Arbuzov str., 8, Kazan, 420088

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