Synthesis of ethyl-4-aryl-2-imino-1-(2-methoxyphenyl)-5-(2-methoxyphenylcarbamoyl)-6-oxopiperidine-3-carboxylates

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Abstract

The reaction of ethyl 3-aryl-2-cyanoprop-2-enoates with N1,N3-bis(2-methoxyphenyl)propanediamide afforded previously unknown products of intramolecular heterocyclization of the primary Michael adducts, ethyl 4-aryl-2-imino-1-(2-methoxyphenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-oxopiperidine-3-carboxylates, in 73–90% yields. The product structure was determined by IR and NMR (1H, 13C) spectroscopy.

About the authors

A. Kh. Khachatryan

Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA; Crisis Management State Academy, MIA RA

Author for correspondence.
Email: khachatryan-ax@mail.ru
ORCID iD: 0000-0003-1210-9903
Armenia, prosp. Azatutyan, 26, Yerevan, 0014; ul. Acharyana, 1, Yerevan, 0040

K. A. Avagyan

Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: khachatryan-ax@mail.ru
ORCID iD: 0000-0002-5370-041X
Armenia, prosp. Azatutyan, 26, Yerevan, 0014

A. A. Sargsyan

Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: khachatryan-ax@mail.ru
ORCID iD: 0000-0002-0303-0710
Armenia, prosp. Azatutyan, 26, Yerevan, 0014

A. E. Badasyan

Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: khachatryan-ax@mail.ru
ORCID iD: 0000-0003-3574-5443
Armenia, prosp. Azatutyan, 26, Yerevan, 0014

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