Reaction of Tetrahydropyrimidine-2(1H)-thione Derivatives with Thiolated Acid Hydrazides as a Method of Synthesis of Biologically Active Ligands of Gold Glyco-Nanoparticles

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Abstract

The reaction of 4-hydroxy-1-phenyl-6-methyltetrahydropyrimidine-2(1H)-thione with 6-mercaptohexanoic and lipoic (thioctic) acids hydrazides in yields of 60–75% to form 4-[ω-(mercaptoacyl)hydrazino]-tetrahydropyrimidine-2(1H)-thiones as a promising сo-ligands for the preparation of gold glyco-nanoparticles for biomedical purposes.

 

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About the authors

A. Y. Ershov

Institute of Macromolecular Compounds of the Russian Academy of Sciences

Author for correspondence.
Email: ershov305@mail.ru
ORCID iD: 0000-0002-2266-4380
Russian Federation, Bolshoi pr., 31, St. Petersburg, 199004

I. V. Lagoda

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation

Email: ershov305@mail.ru
ORCID iD: 0000-0002-3906-2909
Russian Federation, Lesoparkovaya ul., 4, St. Petersburg, 195043

A. A. Martynenkov

Institute of Macromolecular Compounds of the Russian Academy of Sciences

Email: ershov305@mail.ru
ORCID iD: 0000-0002-0951-1451
Russian Federation, Bolshoi pr., 31, St. Petersburg, 199004

A. A. Batyrenko

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation

Email: ershov305@mail.ru
ORCID iD: 0000-0001-9688-3650
Russian Federation, Lesoparkovaya ul., 4, St. Petersburg, 195043

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  5. Ершов А.Ю., Мартыненков А.А., Лагода И.В., Батыренко А.А., Драчев И.С., Якунчикова Е.А., Федорос Е.И., Круглов С.С., Копаница М.А., Якиманский А.В. ЖОХ. 2022, 92, 788–798. [Ershov A.Yu., Martynenkov A.A., Lagoda I.V., Batyrenko A.A., Drachev I.S., Yakunchikova E.A., Fedoros E.I., Kruglov S.S., Kopanitsa M.A., Yakimansky A.V. Russ. J. Gen. Chem. 2022, 92, 850–859.] doi: 10.1134/S1070363222050140
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