Synthesis and conversions of benzo-substituted 1-[2-methyl4-(methyltio)quinolin-3-yl]propan-2-ones

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Abstract

New derivatives of Schiff bases were synthesized using 1-[2-methyl-4-mercaptoquinolin-3-yl]propan-2-ones and 1-[2-methyl-4-(methylthio)quinoline substituted in the benzene ring-3- yl]propan-2-ones as starting materials. To obtain the 4-methylthio derivatives of the Schiff base, the corresponding 4-mercaptoquinoline-propan-2-ones and 3-(2-chloroallyl)-4-mercaptoquinolines were first methylated, followed by acid hydrolysis of the chloro allyl group in the latter samples.

About the authors

I. L. Aleksanyan

Yerevan State University

Author for correspondence.
Email: ialeksanyan@ysu.am
ORCID iD: 0000-0002-4039-2323
Armenia, ul. Aleka Manukyana, 1, Yerevan, 375025

L. P. Hambardzumyan

Yerevan State University

Email: ialeksanyan@ysu.am
ORCID iD: 0000-0003-1210-0052
Armenia, ul. Aleka Manukyana, 1, Yerevan, 375025

References

  1. Teja C., Khan F.R.N. Chem.-Asian J. 2020, 15 (24), 4153–4167. doi: 10.1002/asia.202001156
  2. Matada B.S., Pattanashettar R., & Yernale, N.G. Bioorg. Med. Chem. 2021, 32, 115973. https://doi.org/10.1016/j.bmc.2020.115973
  3. Yadav V., Reang, J., Sharma V., Majeed J., Sharma P.C., Sharma K., Giri N., Kumar A., Tonk R.K. Chem. Biol. Drug. Des. 2022, 100 (3), 389–418. doi: 10.1111/cbdd.14099.
  4. Kaur T., Bhandari D.D. Biointerface Res. Appl. Chem. 2023, 13 (4), 355–374. https://doi.org/10.33263/BRIAC134.355
  5. Patel A., Patel S., Mehta M., Patel Y., Patel R., Shah D., Patel D., Shah U., Patel M., Patel S., Solanki N., Bambharoliya T., Patel S., Nagani A., Patel H., Vaghasiya J., Shah H., Prajapati B., Rathod M., Bhimani B., Patel R., Bhavsar V., Rakholiya B., Patel M., and Patel P. Green Chem. Lett. Rev. 2022, 15 (2), 337–372. https://doi.org/10.1080/17518253.2022.2064194
  6. Mokhtar M., Alghamdi K.S., Ahmed N.S., Bakhotmah D., Saleh T.S.J. Enzyme Inhib. Med. Chem. 2021, 36 (1), 1454–1471. https://doi.org/10.1080/14756366.2021.1944126.
  7. Desai N.C., Maheta A.S., Rajpara K.M., Joshi V.V., Vaghani H.V., Satodiya H.M.J. Saudi Chem. Soc. 2014, 18 (6), 963–971. https://doi.org/10.1016/j.jscs.2011.11.021.
  8. Yadav P., Bhalla A. Chemistry Select. 2022, 7, e202201721. https://doi.org/10.1002/slct.202201721
  9. Shivangi S., Kuldeep S., Shivendra S. Curr. Org. Synthes. 2023, 20 (6), 606–629. https://doi.org/10.2174/1570179420666221004143910
  10. Govindarao K., Srinivasan N., Suresh R., Raheja R.K., Annadurai S., Bhandare R.R., Shaik A.B.J. Saudi Chem. Soc. 2022, 26 (3), 101471. https://doi.org/10.1016/j.jscs.2022.101471.
  11. Li K., Li Y., Zhou D., Fan Y., Guo H., Ma T., Wen J., Liu D., Zhao L. Bioorg. Med. Chem. 2016, 24 (8), 1889–1897. https://doi.org/10.1016/j.bmc.2016.03.016.
  12. Batista V.f., Pinto D.C.G.A. and Silva A.M.S. ACS Sustainable Chem. Engineering. 2016, 4 (8), 4064–4078. https://doi.org/10.1021/acssuschemeng.6b01010
  13. Аветисян А.А., Алексаиян И.Л., Саргсян К.С. ЖОрХ. 2007 43 (3) 423–426. [Avetisyan A.A., Aleksanyan I.L., Sargsyan K.S. Russ. J. Org. Chem. 2007, 43 (3) 422–425.] https://doi.org/10.1134/S1070428007030165
  14. Алексанян И.Л., Амбарцумян Л.П. ЖОрХ. 2021, 57 (8), 1170–1176. [Aleksanyan I.L., Hambardzumyan L.P. Russ. J. Org. Chem. 2021, 57 (8) 1289–1294.] https://doi.org/10.1134/S107042802108008X

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