Synthesis and influence of new indole-containing benzo[f]coumarin derivatives on proliferation and redox state of rat glioma cells line c6

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Abstract

For the first time, modification of 2-acetyl-3H-benzo[f]chromen-3-one and 2-[(2E)-3-phenylprop-2-enoyl]-3H-benzo[f]chromen-3-one was carried out due to interaction with indole. It has been established that the resulting benzo[f]coumarin derivatives exhibit antioxidant properties in model systems — they interact with hydrogen peroxide, sodium hypochlorite and regulate the redox state of rat glioma cells line C6, which is manifested by a decrease in the concentration of intracellular hydrogen peroxide and an increase in the level of reduced glutathione. In the presence of exogenous hydrogen peroxide, synthesized benzo[f]coumarin compounds have a protective effect on cells, acting as antioxidants and restoring redox balance. It was found that 2-[3-(1H-indol-3-yl)-3-phenylpropanoyl]-3H-benzo[f]chromen-3-one in micromolar concentrations inhibits the proliferative activity of C6 rat glioma cells by 25–35%.

About the authors

T. A. Kulahava

Institute for Nuclear Problems of BSU

Email: i.mineyeva@yandex.ru
ORCID iD: 0000-0002-1113-7323
Belarus, ul. Bobruiskaya, 11, Minsk, 220006

V. A. Shumski

Institute of Biophysics and cell engineering NAS of Belarus

Email: i.mineyeva@yandex.ru
Belarus, ul. Akademicheskaya, 27, Minsk, 220072

I. V. Mineyeva

Belarusian State University

Author for correspondence.
Email: i.mineyeva@yandex.ru
ORCID iD: 0000-0002-6422-1967
Belarus, prosp. Nezavisimosti, 4, Minsk, 220030

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