Intramolecular Heterocyclization of Quinolyl-Substituted Carbotiamides Into Functionalized 2,4-Dihydro-3H-1,2,4-triazoles and 1,3,4-Thiadiazoles

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Abstract

An economical and straightforward approach has been introduced for the transformation of quinolyl-substituted propanoyl-N-phenylhydrazine-1-carbothioamide into quinolone derivatives encompassing 4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 1,3,4-thiadiazoles through a heterocyclization reaction using a water solution of sodium hydroxide and concentric sulfuric acid. This efficient procedure has proven to yield the desired products with high efficiency (85—98%). The protocol offers advantages such as cost-effectiveness, omission of catalyst or column chromatography, mild reaction conditions, elevated yields.

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About the authors

I. L. Aleksanyan

Yerevan State University

Author for correspondence.
Email: ialeksanyan@ysu.am
ORCID iD: 0000-0002-4039-2323
Armenia, Yerevan

L. P. Hambardzumyan

Yerevan State University

Email: ialeksanyan@ysu.am
ORCID iD: 0000-0003-1210-0052
Armenia, Yerevan

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