SOME PECULIARITIES OF THE ORGANISM’S RESPONSES TO A LONG-TERM INHALATION OF SILICA-CONTAINING SUBMICRON (PREDOMINANTLY, NANOSCALE) PARTICLES IN A REAL INDUSTRIAL AEROSOL

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

Female white rats were exposed in a «nose only» inhalation device to an aerosol containing predominantly submicron (nanoscale included) particles of amorphous silica in a total concentration of 2.6±0.6 or 10.6±2.1 mg/m3, 4 h/day, 5 times a week, during up to 6 months. In an auxiliary experiment with a single-shot intratracheal instillation of these particles, it was shown that they induced a pulmonary cell response comparable with that when administrated a highly cytotoxic and fibrogenic standard quartz dust DQ12. However in a long-term inhalation test, the aerosol investigated proved to be of a very low systemic toxicity and fibrogenicity. This paradox may be explained by a low retention of SiO2 in lungs and other organs due to a relatively high in vivo solubility of those nanoparticles. Nevertheless their genotoxic action and transnasal penetration into the brain urge caution when assessing occupational or environmental hazard of that aerosol.

Авторлар туралы

M. Sutunkova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Хат алмасуға жауапты Автор.
Email: noemail@neicon.ru
Ресей

S. Solovyeva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Ресей

B. Katsnelson

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Ресей

V. Gurvich

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Ресей

L. Privalova

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Ресей

I. Minigalieva

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Ресей

T. Slyshkina

Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor

Email: noemail@neicon.ru
Ресей

I. Valamina

Central Research Laboratory, Ural State Medical University

Email: noemail@neicon.ru
Ресей

V. Shur

Ural Center for Shared Use «Modern nanotechnologies», Ural Federal University

Email: noemail@neicon.ru
Ресей

I. Zubarev

Ural Center for Shared Use «Modern nanotechnologies», Ural Federal University

Email: noemail@neicon.ru
Ресей

D. Kuznetsov

Ural Center for Shared Use «Modern nanotechnologies», Ural Federal University

Email: noemail@neicon.ru
Ресей

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© Sutunkova M.P., Solovyeva S.N., Katsnelson B.A., Gurvich V.B., Privalova L.I., Minigalieva I.A., Slyshkina T.V., Valamina I.E., Shur V.Y., Zubarev I.V., Kuznetsov D.K., 2017


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