Efficiency of treatment of the children with polyarticulary variant juvenile idiopathic arthritis treated by infliximab in combination with methotrexate in comparison with the results of the methotrexate therapy

In article results of research of efficiency treatment infliximab+methotrexate 28 patients are submitted in comparison with results of therapy methotrexate in therapy 41 patients in the age of from 8 till 17 years with polyarticulary variant juvenile idiopathic arthritis. Duration of supervision has made 1 year. Infliximab it was entered intravenously under the following circuit: infusii on 0-th, 2-nd, 6-th нед and further - in each 8 weeks. The doze infliximab at patients juvenile idiopathic arthritis has made 3,0 mg / kg, weights of a body on one introduction. In 46 weeks treatment infliximab+methotrexate has provided development of clinical remission, decrease and normalization of laboratory parameters of activity of the disease, full restoration of function in joints, improvement of quality of life at 81,2 % of patients and at 16 % - at treatment only methotrexate .

children, juvenile idiopathic arthritis, treatment, infliximab, methotrexate