Collagen exchangeof the compact bone tissue in ratswith alloxan diabetes on the baseof applying steroidogenesis blockator

Abstract

The present work aims to evaluate the metabolism of collagen in the solid bone tissue under alloxanic diabetes and in the case when diabetes is combined with the injection of a steroidogenesis blocker. The following parametres were assessed: total collagen, its soluble fractions, free hydroxyproline, collagenolytic activity. In the process of comapring the obtained data, the following differences were singled out: under 'isolated' alloxanic diabetes, an earlier activation of collagen catabolism and a more prolonged inhibition of synthetic processes were evident than in the case of diabetes combined with the injection of aminoglutethimide.