Email this article Adiponectinemia inhypertensive patients depending oncardiovascular complications risk
- Authors: Kiseleva EV1, Kiselyova EV1
-
Affiliations:
- Issue: Vol 12, No 1-2 (2012)
- Pages: 29-32
- Section: Articles
- URL: https://aspvestnik.ru/2410-3764/article/view/25421
- DOI: https://doi.org/10.17816/2072-2354.2012.0.1-2.29-32
- ID: 25421
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Abstract
Purpose - a comparative investigation of the concentration of adiponectin in hypertensive
patients with varying degrees of risk of cardiovascular complications. Materials and Methods.
68 patients with I, II grade arterial hypertension aged 35 to 56, divided into 3 groups depending
on the risk of development of cardiovascular complications, underwent examination,
including echocardiography, ultrasound dopplerography of brachiocephalic vessels , daily
blood pressure monitoring, lipid spectrum, glucose level and adiponectin concentrations in
blood serum. Results. In hypertensive patients with low risk of cardiovascular complications
the concentration of adiponectin decreased by 32% (p <0,05) compared with those in the
control group. Statistically significant negative correlation between adiponectin and low
density lipoproteins levels (r = - 0,234), triglycerides (r = - 0,518), body mass index (r = - 0,554)
indicates the relationship of inflammatory processes and the impairment of lipid metabolism
in hypertensive patients with average risk of cardiovascular complications. In the subgroups
of high risk patients the level of adiponectin was significantly low.
patients with varying degrees of risk of cardiovascular complications. Materials and Methods.
68 patients with I, II grade arterial hypertension aged 35 to 56, divided into 3 groups depending
on the risk of development of cardiovascular complications, underwent examination,
including echocardiography, ultrasound dopplerography of brachiocephalic vessels , daily
blood pressure monitoring, lipid spectrum, glucose level and adiponectin concentrations in
blood serum. Results. In hypertensive patients with low risk of cardiovascular complications
the concentration of adiponectin decreased by 32% (p <0,05) compared with those in the
control group. Statistically significant negative correlation between adiponectin and low
density lipoproteins levels (r = - 0,234), triglycerides (r = - 0,518), body mass index (r = - 0,554)
indicates the relationship of inflammatory processes and the impairment of lipid metabolism
in hypertensive patients with average risk of cardiovascular complications. In the subgroups
of high risk patients the level of adiponectin was significantly low.
References
- Berg A.H., Scherer P.E. Adipose tissue, inflammation, and cardio-vascular disease. Circ Res 2005;96;939-949
- Goldstein B.J., Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 2004;89;2563-2568.; Hopkins T.A., Ouchi N., Shibata R., Walsh K. Adiponectin actions in the cardiovascular system. Cardiovasc Res 2007;74;11-18.
- Iwashima Y., Katsuya T., Ishikawa K. et al. Hypoadiponectinemia is an Independent Risk Factor for Hypertension. Hypertension 2004;43;1318-1323.
- Ohashi K., Kihara S., Ouchi N. et al. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 2006;47;1108-1116.
- Yamauchi T., Nio Y., Maki T. et al. Targeted disruption of Adi-poR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007;13;332-339.
- Mao X., Kikani C.K., Riojas R.A. et al. APPL1 binds to adi-ponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006;8;516-523.
- Szmitko P.O., Teoh H., Stewart D.J., Verma S. Adiponectin and cardiovascular disease : state of the art? Am J Physiol Heart Circ Physiol 2007;292;H 1655-1663.
- I.B., Ait El Mkadem S., Rezsohazy R. et al Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. Biochem Biophys Res Commun 2006;345;1414-1424.
- Goldstein B.J., Scalia R., Ma X.L.Protective vascular and myocardial effects of adiponectin.Nat Clin pract Cardiovasc Med 2009;6:27 - 35
- Wang B., Trayhurn P. Acute and prolonged effects of THF-alpha on the expression and secretion of inflammatory-related adipokines by human adipocytes differentiated in culture. Pflugers Arch 2006;452:418 - 427.
- Yamomoto Y., Hiroso H., Saito I. et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum hight-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clinical Sciences 2002;103:137 - 142.
- Kadowaki T., Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005;26:439 - 451.
- Диагностика и лечение артериальной гипертензии. Национальные клинические рекомендации. Сборник /Под ред. Р.Г. Оганова. - 2-е издание. - М.: Изд-во «Силицея-Полиграф»,2009. - С292 - 332.
- Диагностика и лечение артериальных гипертоний / - Крюков Н.Н., Качковский М.А. Самара. Перспектива. - 2002. 160с.
- Рогоза А.Н. Суточное мониторирование артериального давления //Сердце. - 2002. - Т.1. №5. - С. 240 - 242.
- LangR.M., BiergM., DevereuxR.B. etal. Recommendations for chamber quantification. Guidelines // Eur. J. Echocardiography. - 2006. - Vol.7, № 2. - P.79-108.
- Guidlines for the managment of arterial hypertension. The Task Force for the Managment of Arterial Hypertension of the European Society of Hypertension (ESH) and European Society of Cardiology (ESC) // Eur. Heart J. - 2007 . - Vol. 28, № 12. - P. 1462 - 1536.
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