Diagnostic and prognostic value of serousand intercellularstatus in childrenand teenagers with varioustypes of juvenileidiopathic arthritis
- Authors: Goryunov SA1, Pryanichnikova NS1, Goryunov SA1, Pryanichnikova NS1
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Affiliations:
- Issue: Vol 12, No 1-2 (2012)
- Pages: 135-140
- Section: Articles
- URL: https://aspvestnik.ru/2410-3764/article/view/25554
- DOI: https://doi.org/10.17816/2072-2354.2012.0.1-2.135-140
- ID: 25554
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Abstract
For specification of diagnosis JIA and definition of the importance of pathogenetic changes research of parameters humor immunity, the most informative is shown at the given pathology, namely: a spectrum cytokines: TNF α, IL6, IL1β, IL4, a level spontaneous both stimulation lymphocytes and monocytes - TNF α. Value cytokines is determining in an inductive phase of the immune answer when they cause development of base reactions makrophages and antigen-specificaition cells: interaction of these cells with lymphocytes, activation and proliferation the last, in the certain degree - formation of cells - effector. At late stages of the immune answer, during realization - effector immunity functions the role cytokines becomes less significant. Level both stimulations lymphocytes and monocytes TNF α reflects activity of pathological process and can be used in forecasting outcomes juvenile idiopathic arthritis.
References
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