Peculiarities of serological indicators (specific Ag A and Ig G to gliadine and antibodies to tissue transglutaminase) in children with celiac

The article presents the research results of serological indicators in 108 children ranging in age from 5 months to 18 years with celiac disease who are examined and treated in the gastroenterology department of N.N. Ivanova ММBI city clinical hospital №1. Antibodies to gliadine (AG) class Ig A, Ig G and antibodies to tissue transglutaminase (ATTT) are taken into account as serological markers.
The increase of the AGA than АТТT is more often revealed in the examined patients. In most cases, the increased AG class IgG and most of these changes are recorded in the second group of the children. The increase of antibodies to gliadine is more frequently registered in typical celiac. In the patients with atypical form the increase as AG, so АТТT is revealed. In the children with a latent form, we identify only the increase of the AG class IgG. In the patients ranging in age from 6 to 12 month with the manifestation of celiac the increase of AG and АТТT are more often registered than in other age periods. In the early manifestations of celiac (up to 6 months) the increase of AG is only noted, АТТT remains within the age limit, which may be due to violation of the production in the children of this age.

celiac disease, children, the antibodies, gliadine, tissue transglutaminase