Metabolites levelin blood and enzymes activity inthe liver at acute alcoholicintoxication in ratswith experimental diabetes



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Abstract

On the model of acute alcoholic intoxication at a singl dose 4 g/kg in rats is shown that in 6 hours in blood the level of free fat acids, urea is increased. In 24 hours concentration of glucose, lactate and urea is increased, the level of free fat acids decreases. Activity of glutamatdehydrogenasa and tirosinaminotransferasa in liver at acute alcoholic intoxication increases. In the rats with experimental diabetes (15 day) in 6 hours after an injection of ethanol in blood the level of glucose, urea, triglycerols is increased, the concentration of free amino acids, lactate is lowered. In this condition in liver of experimental animals activity of glutamatdehydrogenasa decreases and tirosinaminotransferasa increases. In 24 hours in blood concentration of triglycerols is lowered very much, the level of urea remains increased.

References

  1. Балаболкин М.И. Диабетология. - М.: Медицина, 2000. - 672 с.
  2. Bell R.A., Mayer-Davis E.J., Martin M.A. et al. Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors: the Insulin Resistance and Atherosclerosis Study. // Diabetes Care. - 2000. - Vol. 23. - Р.1630-1636.
  3. Beulens W.J., Beers R.M., Stolk R.P.et al. The effect of moderate alcohol consumption on fat distribution and adipocytokines. // Obesity. - 2006. - Vol. 14. - №1. - Р. 60-66.
  4. Дедов И.И., Шестакова М.В. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. - М., 2009. - 104 c.
  5. Лабораторные методы исследования в клинике / Под ред. В.В.Меньшикова. - М.: Медицина, 1987. - 368 с.
  6. Методы биохимических исследований: Липидный и энергетический обмен / Под ред. М.И. Прохоровой. - Л., 1982. - 272 с.
  7. Левин Ф.Б. Простой спектрофотометрический метод определенияактивности тирозинаминотрансферазы. // Вопр. мед. химии. - 1969. -T. 15. - № 3. - c. 315-317.
  8. Yu Bo, Schroeder A., Nagy L.E. Ethanol stimulates glucose uptake and translocation of GLUT-4 in H9c2 myotubes via a Ca2-dependent mechanism // Am. J. Physiol. Endocrinol. Metab. - 2000. - Vol. 279. - P.1358-1365.
  9. Horber F. F., Haymond M. W. Human growth hormone prevents the protein catabolic side effects of prednisone in humans // J. Clin. Invest. - 1990. - V. 86. - P. 265-272
  10. Дедов И.И., Шестакова М.В. Сахарный диабет. Руководство для врачей. - М, 2003. - 445 c.
  11. Баженов Ю.И., Баженова А.Ф., Волкова Я.Ю., Влияние этанола на физиологические функции организма. // Вестник Ивановского государственного университета. Серия «Биология. Химия. Физика. Математика». - 2002. - Выпуск 3. - C. 3-13.

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Copyright (c) 2012 Zharkova N.V., Stel'makh A.Y., Medvedeva N.B., Zharkova N.V., Stelmakh A.Y., Medvedeva N.B.

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