Synthesis and aminomethylation of A-azepanederivatives of uvaol and betulin

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Abstract

By stepwise conjugation of biologically active A-azepanobetulin or A-azepanouvaol with succinic anhydride and propargylamine, followed by a Cu-catalyzed Mannich reaction, new hybrid derivatives with an N -methylpiperazine fragment were synthesized with an average yield of 73%. The structure of the obtained compounds was established using NMR spectroscopy.

About the authors

A. V Petrova

Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science

Email: pnastya08@mail.ru

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