Synthesis and aminomethylation of A-azepanederivatives of uvaol and betulin

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Resumo

By stepwise conjugation of biologically active A-azepanobetulin or A-azepanouvaol with succinic anhydride and propargylamine, followed by a Cu-catalyzed Mannich reaction, new hybrid derivatives with an N -methylpiperazine fragment were synthesized with an average yield of 73%. The structure of the obtained compounds was established using NMR spectroscopy.

Sobre autores

A. Petrova

Ufa Institute of Chemistry of the Ufa Federal Research Centre of the Russian Academy of Science

Email: pnastya08@mail.ru

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