New Chemical Transformation of Substituted Dinitroacetonitrile in the Reaction with Isoquinoline in Presence of Acetylene Dicarboxylic Acid Dimethyl Ester

E. A. Yurtaeva; Юртаева Е. А.; A. G. Tyrkov; Тырков А. Г.

doi:10.31857/S0514749224090026

New Chemical Transformation of Substituted Dinitroacetonitrile in the Reaction with Isoquinoline in Presence of Acetylene Dicarboxylic Acid Dimethyl Ester

Authors: Yurtaeva E.A.¹, Tyrkov A.G.²
Affiliations:
1. Pyatigorsk Medical and Pharmaceutical Institute — Branch of Volgograd State Medical University
2. Astrakhan State University named V.N. Tatishchev
Issue: Vol 60, No 9 (2024)
Pages: 962-966
Section: Articles
URL: https://aspvestnik.ru/0514-7492/article/view/681710
DOI: https://doi.org/10.31857/S0514749224090026
EDN: https://elibrary.ru/QNYQQH
ID: 681710

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Abstract
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Abstract

The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of acetylene dicarboxylic acid dimethyl esters results in the formation of 1,3-dipolar cycloaddition products — a mixture of diastereomeric dimethyl-2-dinitromethyl-1,1вH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.

Keywords

substituted dinitroacetonitrile, isoquinoline, acetylene dicarboxylic acid dimethyl ester, three-component heterocyclization, 1,3-dipolar cycloaddition, dimethyl-2-dinitromethyl-1,1вH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates

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About the authors

E. A. Yurtaeva

Pyatigorsk Medical and Pharmaceutical Institute — Branch of Volgograd State Medical University

Email: tyrkov@rambler.ru
ORCID iD: 0000-0002-1639-1881
Russian Federation, prosp. Kalinina, 11, Pyatigorsk, 357532

A. G. Tyrkov

Astrakhan State University named V.N. Tatishchev

Author for correspondence.
Email: tyrkov@rambler.ru
ORCID iD: 0000-0003-3229-5248
Russian Federation, pl. Shaumyana, 1, Astrakhan, 414000

References

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