Мақаланы E-mail арқылы жіберу Synthesis and Evaluation of the Neurotropic Activity of New Tetrahydropyridazin-3-one Derivatives
- Авторлар: Khachikyan R.D.1, Hovakimyan Z.G.1, Panosyan G.A.1, Mirzoyan L.S.1, Paronikyan R.G.1
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Мекемелер:
- The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
- Шығарылым: Том 60, № 11 (2024)
- Беттер: 1159-1164
- Бөлім: Articles
- URL: https://aspvestnik.ru/0514-7492/article/view/682502
- DOI: https://doi.org/10.31857/S0514749224110103
- EDN: https://elibrary.ru/QHGOZX
- ID: 682502
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
It was established that 4-aryl-4-oxo-2-indol-3-yl butanoic acid and its derivatives upon interaction with hydrazine form 6-aryl-4-[(unsubstituted and substituted) indol-3-yl]-2, 3, 4, 5-tetrahydropyridazin-3-ones, while similarly constructed 4-aryl-4-oxo-2-heterylbutanoic acids under similar conditions are heterocyclized with subsequent azole elimination, resulting in the formation of 6-aryl-2,3-dihydropyridazin-3-ones. The study of the neurotropic activity of new tetrahydropyridazinones derivatives showed that all of the studied substances have anxiolytic action.
Негізгі сөздер
Авторлар туралы
R. Khachikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0006-2014-7861
Армения, Azatutyan Ave. 26, Yerevan, 0014
Z. Hovakimyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0000-1604-5834
Армения, Azatutyan Ave. 26, Yerevan, 0014
G. Panosyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0000-0001-8311-6276
Армения, Azatutyan Ave. 26, Yerevan, 0014
L. Mirzoyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Хат алмасуға жауапты Автор.
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0003-4915-9805
Армения, Azatutyan Ave. 26, Yerevan, 0014
R. Paronikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0000-0002-3845-6324
Армения, Azatutyan Ave. 26, Yerevan, 0014
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