Enviar artigo por via de e-mail Synthesis and Evaluation of the Neurotropic Activity of New Tetrahydropyridazin-3-one Derivatives
- Autores: Khachikyan R.D.1, Hovakimyan Z.G.1, Panosyan G.A.1, Mirzoyan L.S.1, Paronikyan R.G.1
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Afiliações:
- The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
- Edição: Volume 60, Nº 11 (2024)
- Páginas: 1159-1164
- Seção: Articles
- URL: https://aspvestnik.ru/0514-7492/article/view/682502
- DOI: https://doi.org/10.31857/S0514749224110103
- EDN: https://elibrary.ru/QHGOZX
- ID: 682502
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Resumo
It was established that 4-aryl-4-oxo-2-indol-3-yl butanoic acid and its derivatives upon interaction with hydrazine form 6-aryl-4-[(unsubstituted and substituted) indol-3-yl]-2, 3, 4, 5-tetrahydropyridazin-3-ones, while similarly constructed 4-aryl-4-oxo-2-heterylbutanoic acids under similar conditions are heterocyclized with subsequent azole elimination, resulting in the formation of 6-aryl-2,3-dihydropyridazin-3-ones. The study of the neurotropic activity of new tetrahydropyridazinones derivatives showed that all of the studied substances have anxiolytic action.
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Sobre autores
R. Khachikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0009-0006-2014-7861
Armênia, Azatutyan Ave. 26, Yerevan, 0014
Z. Hovakimyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0009-0000-1604-5834
Armênia, Azatutyan Ave. 26, Yerevan, 0014
G. Panosyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0000-0001-8311-6276
Armênia, Azatutyan Ave. 26, Yerevan, 0014
L. Mirzoyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Autor responsável pela correspondência
Email: khachikyanraya@gmail.com
ORCID ID: 0009-0003-4915-9805
Armênia, Azatutyan Ave. 26, Yerevan, 0014
R. Paronikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID ID: 0000-0002-3845-6324
Armênia, Azatutyan Ave. 26, Yerevan, 0014
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