电邮这篇文章 Synthesis and Evaluation of the Neurotropic Activity of New Tetrahydropyridazin-3-one Derivatives
- 作者: Khachikyan R.D.1, Hovakimyan Z.G.1, Panosyan G.A.1, Mirzoyan L.S.1, Paronikyan R.G.1
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隶属关系:
- The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
- 期: 卷 60, 编号 11 (2024)
- 页面: 1159-1164
- 栏目: Articles
- URL: https://aspvestnik.ru/0514-7492/article/view/682502
- DOI: https://doi.org/10.31857/S0514749224110103
- EDN: https://elibrary.ru/QHGOZX
- ID: 682502
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详细
It was established that 4-aryl-4-oxo-2-indol-3-yl butanoic acid and its derivatives upon interaction with hydrazine form 6-aryl-4-[(unsubstituted and substituted) indol-3-yl]-2, 3, 4, 5-tetrahydropyridazin-3-ones, while similarly constructed 4-aryl-4-oxo-2-heterylbutanoic acids under similar conditions are heterocyclized with subsequent azole elimination, resulting in the formation of 6-aryl-2,3-dihydropyridazin-3-ones. The study of the neurotropic activity of new tetrahydropyridazinones derivatives showed that all of the studied substances have anxiolytic action.
作者简介
R. Khachikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0006-2014-7861
亚美尼亚, Azatutyan Ave. 26, Yerevan, 0014
Z. Hovakimyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0000-1604-5834
亚美尼亚, Azatutyan Ave. 26, Yerevan, 0014
G. Panosyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0000-0001-8311-6276
亚美尼亚, Azatutyan Ave. 26, Yerevan, 0014
L. Mirzoyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
编辑信件的主要联系方式.
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0003-4915-9805
亚美尼亚, Azatutyan Ave. 26, Yerevan, 0014
R. Paronikyan
The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia
Email: khachikyanraya@gmail.com
ORCID iD: 0000-0002-3845-6324
亚美尼亚, Azatutyan Ave. 26, Yerevan, 0014
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