Vol 10, No 7-8 (2010)

We estimated the safety of lipid-lowering pharmacotherapy in 248 elderly patients with stable angina. Rosuvastatin 10 mg/day with esetemib 10 mg/day was administrated to 81 pts of Group 1 with initial high LDL-level. Combination of atorvastatin 20 mg/day with esetemib 10 mg/day was administrated to 84 pts of Group 2 with moderate high LDL-level, while 83 pts of Group 3 with optimal LDL-level received simvastatin 40 mg/day. After 12 months of follow-up period we registered myalgia and/or myasthenia in 6 pts (2,4%), dyspepsia in 11 pts (4,4%) and increasing of transaminases in 9 pts (3,6%). In consideration of clinical significant events we interrupted the course of treatment in 4 pts (1,6%). The main causes among them were severe myalgia and/or myasthenia in 1 pt (0,4%), dyspepsia and gastrointestinal disorders in 3 pts (1,2%).

The research subject was the influence of a 14-day course of complex sanatorium treatment on 48 patients with various vegetative disfunctions of the cardiovascular system (vagotonia, eutonia, sympathicotonia) during a riverboat cruise. The monitored groups showed registered trustworthy differences of cardiovascular system indices and the vegetative status measured both in the initial state and dynamically. The research revealed the existence of a correlation dependency of the Kerdo index and the dynamic segmentary diagnostics data. The discovered tendency to normalization of cardiovascular system indices and the vegetative status proved the efficiency of treatment of patients with vegetative disfunctions during a riverboat cruise.

The study included 138 elderly men. The patients are divided into four groups: first group consisted of patients without clinical manifestations of the cardiovascular system; the second group includes persons with ischemic heart disease, stable angina of functional class II, chronic heart failure in stage I, I-II functional class; the third group - patients with ischemic heart disease, stable angina of functional class II, hypertension 1-3 degrees, congestive heart failure in stage I, I-II functional class. The control group included healthy men of mature age. Shown that elderly patients against coronary heart disease combined with hypertension there are changes in the state of aggregation of blood and found a close correlation relationship between the individual factors of blood aggregation. Only a multi-faceted impact on all indicators of blood aggregation in geriatric patients will create favorable conditions for improving the quality and longevity.

The article analyzed the data dynamics of the volumes of various types of outpatient dental care provided to elderly patients by sex-age groups in GUZ Samara Regional Clinical Dental Clinic.

The majority of mild asthma cases and its low compliance level make investigators search for new instruments to improve asthma control and adherence, especially in this cohort. The goal was to research the new educational instrument of mild asthma management, its influence on the increasing of asthma control and compliance. 186 patients with mild asthma were enrolled in research that took 3 months. There were performed management instruments: personal asthma action plan, control visit with treatment correction and passing electronic educational asthma program. Changes in asthma control and compliance levels were revealed with ACT™ test (Asthma Control Test™), Compliance Index Assessment Questionnaire and in addition with knowledge control test results, immunologic parameters and etc. Educated in that way patients obtained higher asthma control, higher compliance level and were able to do self management finally. This instrument is required to be available to each patient with any form of asthma and should be further used in asthma management.

At present drug addiction is a real threat for the people's health in our country. According the data of the federal statistics observation in 2009 there were 555 thousands of registered drug users, the number of drug addicted is 358 thousands, 87% of them take heroin. That is the reason why a more successful rehabilitation program needs to be created. To make such, we need to narrowly examine the psychological factors of drug addiction, also by means of projective methods, find out what are this factors and how do they influence the possibilities and capabilities of the patients to recreate.

In 74 patients with COPD stage II with erythrocytosis in acute investigated the structural and functional state of the membranes of erythrocytes. Physico-chemical characteristics of erythrocyte membranes studied by determining the content of cholesterol (LDL), total phospholipids (PL) and their ratio (CH / PL), as well as the method of fluorescent probes. Established microviscosity (J286) lipids, calculated the degree of clustering (fragmentation) of the structural proteins (Jkl). To assess the intensity of free radical oxidation (FRO) membranes of red blood cells determined malondialdehyde (MDA) - a secondary stable product FRO. Antioxidant components of oxidative stress (OS) in the membranes of erythrocytes was determined by the level of vitamin E. Established that patients with COPD there is increased compared with healthy people and matrix microviscosity of membrane lipids of erythrocytes, as well as elevated levels of clustering (fragmentation) structural proteins. These phenomena are expressed at significantly greater in patients with significant erythrocytosis and is closely connected with an increased ratio of cholesterol / PL, as well as with higher levels of activity of free radical oxidation of lipid-protein structure of erythrocyte membranes. It can be assumed that the identified changes are the basis of disturbed rheological properties and transport functions of erythrocytes.

Detection of teratogens is the main objective of population monitoring. Risk of major malformations in general population of Samara region was 2,6%. We evaluated outcomes of 280 pregnancies of women with epilepsy. Level of major malformations , including due to genetic and chromosomal disorders , accounted for 2,9 %. We found no clear relationship between the frequency of major malformations, and taking his mother antiepileptic drugs.

In this paper the phenotypical women with the signs of connective tissue displaceability were intercommunicate. Anamnesis date were investigated between 500 women of reproductive age, somatic profile state and the signs of connective tissue displaceability were assessed according to S.N. Buyanova and coauthors' scale. Determination method was used to analyze the received data. The results of the research showed that asthenia, post gravidarum striae, greater brittleness of nails, frequent headaches, osteochondrous, eyesight disorders, flat foot, varicosity and vasoneurosis refer to the most common phenotypical signs. Correlation dependence of obstetrical gynecological pathologies are less important. But we should pay attention to this problem when we deal with prediction development of gynecological disorders.

The aim of research: to reveal the criteria of development of postabortion andometris taking clinical morphological parallels into account.Research material: 100 women with clinical signs of the complicated abortions and 80 women with spontaneous abortions without complications; andometris analyses at 180 women with spontaneous abortions in term till 22 weeks of pregnancy and at 10 women at medical interruption of pregnancy.Results of research: the most significant pathogenetic risk factors of development of andometris after spontaneous abortions is promiscuity (20 %), extragenital pathology, in particular diseases urogenitalis systems (44 %), use of intrauterine contraception (21 %), and also a gynecologic pathology: nonspecific (87 %) and specific (55 %) inflammatory diseases of female genitals, infringement of a menstrual cycle (18 %).The conclusion: for decrease in frequency of development of complications after spontaneous abortions and improvement of quality of individual treatment-and-prophylactic rehabilitation actions it is necessary to consider morphological and morfomatrical criteria of development of andometris.

The basic principles of mathematic modeling are consistently considered and «The prognostic table that estimates risk of vertical transmission of mother-fetal AIDS-infection» was the result. The interpretation of risking factors and their informational value is given. The developed technique allows to allocate the high-risk realization group of vertical transmission of AIDS- infection for purposeful and effective preventive work in investigated region.

The analysis of efficiency of the new scientifically-based system of early prevention of a perinatal pathology in Samara health care system on the basis of studying of health state of pregnant women and newborn children for 1997-2008 is carried out. Correctness of the chosen strategy of protection of population health is proved by an unidirectional tendency of decrease in perinatal and infantile death rate and disease of newborns.

In article the data about psychological features of children of school age with a functional dyspepsia is cited. High prevalence of uneasiness and internal intensity is shown. Influence family and social factors on formation FD, in particular adverse conditions of residing, low material security and, especially, disharmonious family relations (90,1 % of cases) is taped. As results of the spent symptomatic and complex therapy including psychological correction were estimated. At the schoolboys receiving complex treatment in 2 times is more often full cupping of symptoms of disease became perceptible and in 2 times resistance to spent therapy was less often registered, positive dynamics of psychological changes became perceptible. At children by whom symptomatic therapy was spent, internal intensity, uneasiness, isolation during research accrued.

This article covers cause-effect relations between primary defect (impairment of vision), content of therapeutic and restorative, correctional and teaching activities, which are to be taken into consideration in the course of constructive performance development among preschool children with strabismus and amblyopia. The authour gives a list of recommendations on how to strengthen the effect of eyesight treatment, which discover the rehabilitation potential of constructive performance.

In clause the immune factors influencing on the pathogenesis of a chronic virus hepatites B and C at children are considered. For the characteristic of the immune answer at patients with CVH B and CVH С in the replicative and integration phases we study a sufficient spectrum cytokines. Researches of whey of blood of children sick of a chronic virus hepatites В and h in replicative and integration of a phase on a parity of a level cytokines were carried out. Interrelations cytokines with cytolysis at children with a chronic virus hepatites В and have been considered С.

This article reflects the current ideas about the treatment of diffuse toxic goiter (DTG) abroad and in Russia. Summarizes the pros and cons of the basic methods and treated in different countries. Presents the experience of surgical treatment of 185 patients with Graves' disease and the analysis of long-term results and quality of life of 92 patients with this pathology in the period from 1 year to 10 years.

Treatment of patients with crises of proximal department of a humeral bone is an important problem of modern traumatology. In our work we have carried out the analysis of treatment of 150 patients with the given trauma which have been divided into three clinical groups, depending on a way of medical intervention. Application of the new approach to treatment of patients with crises of proximal department of the humeral bone including use of a way of surgical treatment of given patients, the tool for performance of the most responsible stage of operation and devices for carrying out of the regenerative period, has allowed to lower number of failures from 77,8 % to 24,3 %.

The results of neoangiogenesis has been studied for the treatment of 42 patients with arterial atherosclerosis occlusive disease of lower extremities who are not candidates for treatment surgical. We studied the results in the 3 groupies including 14 patients in the each. Autological progenitor cells (CD 133+) were transplanted in I-st group. Leucocytes bone morrow cells (CD 34+) were transplanted in II group. The patients of III group was injected isotonic solution as a placebo. All of solutions were injected in internal and external muscles of shin. We appreciated our clinical results in Rutherford's scale. In conclusion, we observed what the improvement of clinical condition in patients (with a transplantation of CD 133+ and CD 34+ of I and II groups) was trustworthy by Mann-Whitney's criterion.

This article presents the detailed morphological structure of urinary bladder neoplasms of 628 patients who have undergone surgical treatment in urological hospitals of Republic Mordovia. The analysed histological material in 76 % cases showed malignant tumors. The diagnostics indicates that incorrectly executed biopsy in 38 % gives a false negative result and subsequently it confirms by incisional biopsy. In 12 % of cases when urinary bladder transurethral resection is executed the presence of malignant growth also doesn't confirm.

The aim of the work was to improve the results of pulmonary resection by developing and implementing ways of sealing the wounds of biological adhesives, and drugs. Were analyzed the results of applying additional methods sealing line of manual and mechanical suture after atypical resection of the lung/.Methods of aerial and hemostasis are particularly necessary for emphysematous changes in pulmonary tissue. Application of differential approach to the choice of sealing the seam line to reduce the number of complications in the postoperative period.

There are various clinical symptoms and methods of complex treatment of TMJ osteoarthrosis, caused by a chronic microtrauma. Within the research project, 52 patients aged from 41 to 64 years old have been diagnosted with TMJ osteoarthrosis, on the basis of electromyography, a computer tomography, registration of movements of the mandibula, results. The results of the research work have allowed to develop medical treatment plan directed to restore the height of the lower part of the face, normalisation of occlusial relations and elements of TMJ, the ligament-muscular system.

There is an increasing tendency for computer tomography to be in a strong position in diagnostics of stomatological nosological forms. In this article the comparative informative analysis of intraoral dental roentgenography, orthopanthomography and dental CT in diagnostics of root extraction in the same patients is presented. Based on our findings high efficiency of dental CT in comparison with other methods of beam diagnostics is shown.

Тhe purpose of the present research was the estimation of а condition of personnel maintenance of establishments of public health services in Ingushetia Republic. Dynamics of indicators of security Ьу medical shots of republic for the eight-year period оп various specialities was studied, distinctive features of region in maintenance with medical shots of treatment-and -prophylactic establishments of republic for performance of existing volumes of medical aid were revealed.

The spent comparison of the sizes of average wages of local medical sisters of city district Samara in nominal expression for the investigated periods shows its growth. Use as a tally of size of a living wage allows to reveal only small increase in the relative size of wages. Thus, use of new system of a payment by heads of medical institutions in city district Samara has led to increase of the size of wages of local medical sisters even in nominal expression of a part of establishments, and growth of real purchasing capacity of the paid wages taking into account an index-defljatora was negative in all establishments, however the range of degree of decrease was considerable enough. The carried out analysis of efficiency of new system of a payment in public health services in system of municipal public health services an city district Samara was shown by absence of positive changes in increase of level of a payment in real expression of local medical sisters and decrease in differentiation of work of workers of the higher and lowest qualification in comparison with the Uniform scale of charges.

It is presented findings analysis of literature data concerning to the history of Samarkand during the Karakhanids' period. Were indicated the merits of some Samarkand medical-scientists in the field of pharmacy, surgery, diagnostics, therapy and antiseptics in the XI-XVI centuries. Key words: history of medicine, Samarkand, Movarounnaxr, medical - scientists.